Test of The Effectiveness of Sweet Wood (Cinnamomum Burmanii) on Healing of Wood Wounds in Wistar Rats
DOI:
https://doi.org/10.59188/eduvest.v5i1.50271Keywords:
Incised wounds, cinnamon extract, wound healing, Cinnamomum burmanii, anti-inflammatory, antioxidant, antibacterialAbstract
Incised wounds are disruptions of skin integrity that require effective treatment to accelerate healing. Cinnamon (Cinnamomum burmanii), rich in secondary metabolites such as eugenol, cinnamaldehyde, and flavonoids, is known for its potential as an anti- inflammatory, antioxidant, and antibacterial agent. This study aims to evaluate the effectiveness of cinnamon extract ointment in healing incised wounds in Wistar rats. This experimental study used a post-test only control group design. A total of 30 Wistar rats were divided into five groups: a negative control (ointment base), a positive control (gentamicin ointment), and three treatment groups with cinnamon extract ointments at concentrations of 10%, 20%, and 40%. Observations of wound length and healing percentages were conducted over 14 days. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed a significant reduction in wound length in the 40% cinnamon extract ointment group (19.6 mm) compared to the negative control (12.8 mm) and were close to the effectiveness of gentamicin ointment (20 mm). The highest wound healing percentage was also achieved in the 40% concentration group (98.2%), comparable to gentamicin ointment (100%). Cinnamon extract ointment at a concentration of 40% effectively accelerates the healing of incised wounds in Wistar rats, with effectiveness comparable to gentamicin ointment. Further research is needed to evaluate its safety and clinical potential.
References
Anggraini, R. D. D., Purwati, E., & Safitri, C. I. N. H. (2021). Formulasi Dan Stabilitas Mutu Fisik Ekstrak Kayu Manis ( Cinnamomum Burmannii ) Sebagai Bedak Padat Antioksida. Seminar Nasional Pendidikan Biologi Dan Saintek (Snpbs) Ke-Vi 2021 |, 603–610.
Antasionasti, I., & Jayanto, I. (2021). Aktivitas Antioksidan Ekstrak Etanol Kayu Manis ( Cinnamomum Burmani ) Secara In Vitro. Jurnal Farmasi Udayana, 10(1), 38–47. Https://Doi.Org/Https://Doi.Org/10.24843/Jfu.2021.V10.I01.P05
Anu, H. V., Amat, A. L. Sh., & Sasputra, I. N. (2019). Perbandingan Efektivitas Ekstrak Pegagan ( Centella Asiatica ( L .) Urban ) Dengan Salep Gentamisin Terhadap Penyembuhan Luka Insisi Tikus Putih Sprague Dawley. Cendana Medical J, 18(3), 472–478.
Bunganaen, Dkk. (2019). Studi Komparatif Efektivitas Pemberian Ekstrak Daun Lamtoro(Leucaena Leucocephala) Dan Salep Gentamisinterhadap Penyembuhan Luka Sayat Kulit Mencit (Mus Musculus). Cendana Medical Journal (Cmj), 8(1), 512–520.
Carvalho, M. T. B., Araújo-Filho, H. G., Quintans-Júnior, L. J., Quintans, J. S. S., & Barreto, R. S. S. (2021). Phytomedicine Wound Healing Properties Of Flavonoids : A Systematic Review Highlighting The Mechanisms Of Action. Phytmedicine, 90(February), 1–15. Https://Doi.Org/10.1016/J.Phymed.2021.153636
Djarot, P., Utami, N. F., Yulianita, Y., Novitasari, N., & Fitriyani, W. (2021). Potensi Ekstrak Refluks Kulit Batang Kayu Manis (Cinnamomum Burmanii) Sebagai Antijamur Candida Albicans Dan Candida Tropicalis. Fitofarmaka: Jurnal Ilmiah Farmasi, 11(2), 164–178. Https://Doi.Org/10.33751/Jf.V11i2.2722
Djuddawi, M. N., Haryati, & Kholidha, A. N. (2022). Uji Efektivitas Ekstrak Serai ( Cymbopogon Citratus ) Terhadap Penyembuhan Luka Sayat Pada Mencit Putih. Jurnal Surya Medika, 5(1), 12–21. Https://Doi.Org/10.33084/Jsm.V5i1.942
Fadhilah, H., Indah, F. P. S., & Febriza, S. (2022). Studi Literatur Efektivitas Tanaman Terhadap Penyembuhan Luka Sayat. Edu Masda Journal, 6(1), 1–9. Https://Doi.Org/10.52118/Edumasda.V6i1.143
Faizah, K. (2024). Original Article *) Efektifitas Cairan Kayu Manis Terhadap Penyembuhan Luka Perineum Derajat 2 Pada Ibu Nifas Di Tpmb Kuswatun Faizah Jakarta Barat. Dpoaj, 3(11), 1486–1491.
Gusriati, Yolandia, R. A., & Putri, R. (2023). Pengaruh Pemberian Kayu Manis Terhadap Penyembuhan Luka Perineum Pada Ibu Nifas Di Puskesmas Lembang Kabupaten Garut Tahun 2023. Sentri: Jurnal Riset Ilmiah, 2(10), 4305–4317.
Irawan, W. K., Kurniawaty, E., & Rodiani. (2023). Zat Metabolit Sekunder Dan Penyembuhan Luka : Tinjauan Pustaka. Agromedicine, 10(1), 26–30.
Maan, J. S. Y., Sasputra, I. N., & Wungow, H. P. L. (2020). Perbandingan Efektivitas Pemberian Ekstrak Rimpang Kunyit(Curcuma Domestica Val) Dan Salep Gentamisin Terhadap Penyembuhan Luka Sayat Kulit Mencit (Mus Musculus). Cendana Medical Journal, 19(1), 147–155.
Marissa Rijoice, & Saragih, H. (2022). Mengekstrak Senyawa Bioaktif Yang Terkandung Pada Kulit Kayu Manis Dan Mengidentifikasinya Dengan Teknik Gas Chromatography – Mass Spectroscopy (Gc-Ms). Jurnal Biologi Dan Pembelajarannya (Jb&P), 9(1), 12–26. Https://Doi.Org/10.29407/Jbp.V9i1.17633
Megawati, S., Ummah, U. C., & Setiawan, A. A. (2020). Formulasi Dan Uji Efektivitas Penyembuhan Luka Sayat Salep Ekstrak Metanol Bunga Ginje ( Thevetia Peruviana ) Terhadap Kelinci Jantan New Zealand White. Jurnal Farmasi Udayana, 9(2), 180–186. Https://Doi.Org/Https://Doi.Org/10.24843/Jfu.2020.V09.I02.P06
Pakpahan, K. Y., Yamlean, P. V. Y., & Jayanto, I. (2020). Formulasi Dan Uji Antibakteri Gel Ekstrak Etanol Daun Kedondong (Spondias Dulcis) Terhadap Bakteri Pseudomonas Aeruginosa. Pharmacon, 9(1), 8–15.
Primadina, N., Basori, A., & Perdanakusuma, D. S. (2019). Proses Penyembuhan Luka Ditinjau Dari Aspek Mekanisme Seluler Dan Molekuler. Qanun Medika-Medical Journal Faculty Of Medicine Muhammadiyah Surabaya, 3(1), 31–43.
Rasyid, R. S. P., Liberty, I. A., & Subandrate. (2020). Gambaran Histologi Ketebalan Jaringan Granulasi Pada Tikus Wistar Jantan Dengan Luka Bakar Setelah Pemberian Ekstrak Kayu Manis (Cinnamomun Burmanii). Jurnal Kedokteran Dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 7(1), 9–15. Https://Doi.Org/Doi :10.32539/Jkk.V7i1.7609
Sani, F. K., Samudra, A. G., Rahman, H., & Rahman, A. O. (2022). Efektivitas Khasiat Penyembuhan Luka Sayat Gel Ekstrak Etanol Daun Ekor Naga ( Rhaphidophora Pinnata ( L . F ) Schott ) Berdasarkan Analisis Hidroksiprolin. Jurnal Farmasi Sains Dan Terapan (Journal Of Pharmacy Science And Practice), 9(2), 60–66. Https://Doi.Org/10.33508/Jfst.V9i2.4084
Schink, A., Naumoska, K., Kitanovski, Z., Kampf, C. J., Fröhlich-Nowoisky, J., Thines, E., Pöschl, U., Schuppan, D., & Lucas, K. (2018). Anti-Inflammatory Effects Of Cinnamon Extract And Identification Of Active Compounds Influencing The Tlr2 And Tlr4 Signaling Pathways. Food And Function, 9(11), 5950–5964. Https://Doi.Org/10.1039/C8fo01286e
Shazeli, M., Zain, C., Lee, S. Y., Sarian, M. N., Fakurazi, S., & Shaari, K. (2020). In Vitro Wound Healing Potential Of Flavonoid C -Glycosides From Oil Palm ( Elaeis Guineensis Jacq .) Leaves On 3t3 Fibroblast Cells. Antioxidants, 9(326), 1–18.
Suryandari, S. S., Queljoe, E. De, & Datu, O. S. (2021). Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Sesewanua (Clerodendrum Squamatum Vahl.) Terhadap Tikus Putih (Rattus Norvegicus L.) Yang Diinduksi Karagenan. Pharmacon, 10(3), 1025–1032.
Susanto, Y., Solehah, F. A., Fadya, A., & Khaerati, K. (2023). Potensi Kombinasi Ekstrak Rimpang Kunyit (Curcuma Longa L.) Dan Kapur Sirih Sebagai Anti Inflamasi Dan Penyembuh Luka Sayat. Jpscr: Journal Of Pharmaceutical Science And Clinical Research, 8(1), 32. Https://Doi.Org/10.20961/Jpscr.V8i1.60314
Tagousop, C. N., Tamokou, J. D. D., Kengne, I. C., Ngnokam, D., & Nazabadioko, L. V. (2018). Antimicrobial Activities Of Saponins From Melanthera Elliptica And Their Synergistic Effects With Antibiotics Against Pathogenic Phenotypes. Chemistry Central Journal, 12(97), 1–9. Https://Doi.Org/10.1186/S13065-018-0466-6
Tamuntuan, D. N., Queljoe, E. De, & Datu, O. S. (2021). Uji Efektivitas Penyembuhan Luka Sediaan Salep Ekstrak Rumput Macam( Lantana Camara L ) Terhadap Luka Sayat Pada Tikus Putih Jantan Rattus Norvegicus). Pharmacon, 10(3), 1040–1049.
Wang, X., Decker, C. C., Zechner, L., Krstin, S., & Wink, M. (2019). In Vitro Wound Healing Of Tumor Cells : Inhibition Of Cell Migration By Selected Cytotoxic Alkaloids. Bmc Pharmacology And Toxicology, 4(4), 1–12.
Yuwanda, A., Adina, A. B., & Budiastuti, R. F. (2023). Kayu Manis (Cinnamomum Burmannii (Nees & T. Nees) Blume): Review Tentang Botani, Penggunaan Tradisional, Kandungan Senyawa Kimia, Dan Farmakologi. Journal Of Pharmacy And Halal Studies (Jphs), 1(1), 17–22. Https://Doi.Org/10.70608/3mk0s904
Zainal, T. H., Nisa, M., Hikma, N., Arifin, A. A., & Uji, A. A. (2024). Uji Efektivitas Penyembuhan Luka Film Forming Gel Gentamisin Pada Model Tikus Diabetes. Jurnal Mandala Pharmacon Indonesia, 10(2), 681–687.
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